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Many plans impose step therapy requirements, forcing patients to fail cheaper agents first before approving expensive GLP-1s

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It should be used as a supplement to a balanced diet and not as a substitute for medical treatment

The advent of personalized and engineered probiotics introduces further complexity, as factors such as individual microbiome variability, host genetics, and polypharmacy can influence both the efficacy and safety profiles, thereby complicating standardized evaluation (527, 528)

1 2 "Lilly Statement Regarding NIH's ACTIV-3 Clinical Trial"