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Subramaniam SR, Chesselet MF

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Finally, the application of redesigned protein evolution developed a selection-specific and stable ataxin-2-cleaving protease with no detected native substrate cleavage, which was not achieved by evolving the starting point without redesign

Because triamterene is a weak folic acid antagonist, megaloblastic anemia has been reported in patients with decreased folic acid stores

Our results partly support the hypothesis that accelerated cellular aging in individuals with psychiatric conditions could be a reversible process 66 , and that some of these effects, to the extent they exist, may be mediated via mechanisms involving telomerase and/or an antioxidant enzyme systems