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These effects usually improve within 24 weeks
This is the form studied in the two published human trials
The control group was significantly different than the current time point for both medications (Semaglutide: B = 10.29, SE = 3.02, p = 0.004, Tirzepatide: B = 11.445, SE = 3.08, p = 0.003), but was not different when compared to prior to starting each medication (n.s.)
Final Thoughts While there is no definitive timeline for how long you should stay on GLP-1 medications for weight loss, most people will benefit from a structured approach that spans 6-12 months, with adjustments as necessary based on individual progress and goals
In the brain, Ang II increases sympathetic discharge and decreases vagal discharge