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Lentigo maligna is an early form of melanoma in which the malignant cells are confined to the tissue of origin, the epidermis, hence it is often reported as in situ melanoma

For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig

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We often remind our patients that surgery removes the excess skin, but lifestyle choices preserve the results, notes Dr

doi: 10.1128/JVI.02246-18 20 ChowdhuryFZRamosHJDavisLSFormanJFarrarJD

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