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However, current evidence primarily supports an associative relationship rather than a causal link between physical inactivity and neuroinflammation in COPD [83]

Lin L, Yang J, Zhang D et al (2023) Vascular endothelial growth factor A contributes to increased mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

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This cycle continues with the newly formed L-citrulline converting back to L-arginine, creating a sustainable supply of NO precursors

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