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The role of a DPP-4 inhibitor is long-term glucose support, not rapid correction of an urgent problem

These are most pronounced during dose escalation, the weeks immediately following a dose increase, and they typically diminish over time as the body adjusts

doi: 10.1039/d2ra07673j

Propionyl-L-carnitine is an orally active L-carnitine derivative

These side effects, if they occur, may last for a substantial period of time or even be permanent

Mutant mice were born with red, shiny skin that rapidly dried and died, lacking typical ichthyosiform lesions ( Alox12b loss-of-function mutant mouse skin grafts can develop local ichthyosiform manifestations when matured on nude mice