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Key points Blood pressure is determined by the interplay of genetic factors including rare variants with large effect sizes that cause monogenic hypertension syndromes and common variants with small effect sizes that contribute to polygenic cases of hypertension and non-genetic factors such as diet and the microbiome

doi: 10.2147/NDT.S260160 161 MaDLChenFQXuWJYueWZYuanGYangY

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Relaxin, on the other hand, enhances matrix metalloproteinase (MMP) activity, enzymes that degrade collagen and other extracellular matrix components, resulting in a more compliant ligament