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The FDA label lists this explicitly

Pharmacodynamic interactions where two drugs produce overlapping or additive effectsare more relevant when considering this combination: Additive weight loss effects : Both medications can cause significant weight reduction

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How to track calories when your appetite disappears Tracking calories on semaglutide presents a unique challenge

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It's important to note that while Ozempic may have benefits for heart health, it is not a substitute for other treatments or lifestyle changes that are recommended for people with heart disease or other cardiovascular conditions