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The liver stores are a bit irrelevant to someone who has PA or a B12 absorption problem though because the mechanism that is used to release them relies on the same mechanism that is used to absorb most dietary B12 so accessing any stores is at best very inefficient

Br J Rheumatol 36: 560572

Recent studies also suggest that genetics may play a role in determining individual response

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The first is form: if injecting is a hard no, the oral options (Rybelsus, the oral Wegovy pill, orforglipron) move up the shortlist even though the strongest weight-loss data still sits with the weekly injectables

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, whereas semaglutide only targets the GLP-1 receptors