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Vitamin B-6 is involved in nearly 60 enzyme systems in the body

Additionally, in liver cancer cell lines HepG2 and HepG2.2.15, the expression of -adrenergic receptors (mainly 2 receptors) is significantly higher than in the normal liver cell line HL-7702

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In addition, clinical muscle function studies involving older men and women have observed that participants in the placebo group show declines in muscle strength over the course of the study [40, 41], relative to baseline, similar to this current report

Abbreviations CVOTs: Cardiovascular outcome trials DPP-4 inhibitors: Dipeptidyl peptidase-4 inhibitors GLP-1RA: Glucagon-like peptide-1 receptor agonists SGLT-2 inhibitors: Sodium-glucose cotransporter 2 inhibitors MACE: Major cardiovascular events RR: Risk ratio HHF: Hospitalization for heart failure References IDF Diabetes Atlas 2021 10th edition

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