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Patients with Hepatic Impairment A single-dose, open-label study was conducted to evaluate the pharmacokinetics of phentermine and topiramate extended-release 15 mg/92 mg in healthy volunteers with normal hepatic function compared with patients with mild (Child-Pugh score 5 to 6) and moderate (Child-Pugh score 7 to 9) hepatic impairment

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From a pharmacovigilance perspective, phentermine shows fewer serious adverse events than several newer agents when prescribed as monotherapy

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Monocyte-Macrophages and T Cells in Atherosclerosis