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3.1.2 GLUT9 The focus on URAT1 as the primary driver of urate reabsorption has led to limited exploration of drug development targeting the GLUT9 transporter for hyperuricemia treatment, with most studies conducted in conjunction with URAT1 [97]

The short answer is that splitting a dosetaking 0.25 mg twice a week instead of 0.5 mg once a weekis a strategy some healthcare providers use to help patients manage side effects

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