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The Finding: Recent studies indicate that heightened platelet aggregation in mid-life correlates with early, subtle brain changes associated with AD pathology

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In addition, there was an increase in innate immunity with microglial activation (Poloni et al

[183] [36] [184] On metabolic effects, semaglutide enhances insulin sensitivity primarily through weight loss-mediated mechanisms rather than direct tissue-specific actions independent of body weight changes, accompanied by reductions in blood pressure, inflammatory markers such as C-reactive protein, and improvements in lipid profiles that contribute to lowered cardiovascular risk

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