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Interestingly, GIPR agonism blocks PYY ( Despite the impressive results achieved, weight reduction is still considerably lower than bariatric surgery leaving important unmet medical needs and opportunities for obesity treatments

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

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