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One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37

PMID: 34579623[PubMed Reference] Bock-Marquette I, Saxena A, White MD, et al

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Open the full calculator with storage and FAQ The compound researchers most often pair with this one, plus the bacteriostatic water to reconstitute it

Peer review Peer review information Nature Reviews Rheumatology thanks Devaraj Ezhilarasan, Shunsuke Mori and the other, anonymous, reviewer for their contribution to the peer review of this work