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According to the safety data provided in the prescribing information, common side effects include mild pain or swelling at the injection site, a temporary increase in joint pain, and mild itching or skin irritation

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Funding Statement The authors declare that no financial support was received for the research and/or publication of this article

Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomesan analysis of CENTER-TBI data

NDDS can improve the pharmacokinetic profile of matrine by enhancing its solubility, protecting it from premature degradation, promoting targeted tumor accumulation, and enabling controlled release