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In the early 1960s, researchers found that workers with chronic exposure to organophosphates, mainly in insecticides and after sheep dipping, experienced persistent central nervous system (CNS) changes (153)

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Among them, the hydroquinone-berberine hybrid, had the greatest ability to suppress A aggregation and inhibit oxidative stress ( 3.2 Parkinsons Disease Parkinsons disease, a neurodegenerative disease characterized by muscle stiffness, tremor, speech and gait changes, and its risk factors include environmental factors, genetic factors, gender factors, age, etc

Clin Infect Dis 72(11):e736e741