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# # # Disclosures: Rohit Loomba, MD, is a consultant or advisory board member for Aardvark Therapeutics, Altimmune, Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse bio, Hightide, Inipharma, Intercept, Inventiva, Ionis, Janssen Inc., Madrigal, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Merck, Pfizer, Sagimet, Theratechnologies, 89 bio, Terns Pharmaceuticals and Viking Therapeutics
then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability
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52 MaJ.CaiH.WuT.SobhianB.HuoY.AlcivarA.et al (2012)
Tumor diagnosed as a classic AFX initially is reclassified as PDS after metastases are discovered
