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Figure 2 There is also now ample evidence demonstrating that insulin reaching the liver via the portal system plays an important role in making the liver more GH sensitive to IGF-I generation (41, 42)

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On the contrary, the upregulation of VEGF receptors and Ang/Tie 2 in later stages was correlated with the increase in the number of capillaries and enlarged vessels in the penumbra (201)