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Their work includes chronic dosing studies extending to 6 weeks, comprehensive tissue examination at necropsy, and genetic toxicology assessment using standardized protocols accepted by regulatory agencies worldwide

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In another study, recombinant efgartigimod was found to stabilize keratinocyte monolayers in a cellular model of pemphigus, hinting at a direct role of FcRn in mediating pathological effects of anti-DsG Abs [236]