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While some people might notice subtle changes within a few weeks, the most significant improvements from KLOW therapy typically appear after about 8 to 12 weeks of consistent use

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216 Furthermore, a randomized, double-blind, placebo-controlled trial in 65 hemodialysis patients reported that taking 1,200 mg, but not 600 mg, of CoQ10 daily for four months decreased oxidative stress (as indicated by a decrease in F2-isoprostanes)

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however, requirements vary