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This deficiency can lead to megaloblastic anemia, where the body produces large, abnormal red blood cells that cannot function effectively, resulting in symptoms such as fatigue, weakness, and neurological issues

the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

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Patch test first and stop use if irritation continues

(2013) 8:e67102