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In studies combining NNMTi with other weightloss drugs, coadministration with GLP1 receptor agonists significantly enhances weightloss efficacy while reducing side effects such as nausea and vomiting commonly associated with GLP1 agonists

One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition

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