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The comparison is inherently unequal: semaglutide has decades of development, tens of thousands of patients, and proven cardiovascular benefit

(2) You have heart disease and want the FDA-approved cardiovascular benefit

The oesophagus is separated from the pharynx by the upper oesophageal sphincter (UOS), which is normally closed due to tonic activity of the nerves supplying the cricopharyngeus

Recent systematic reviews and meta-analyses demonstrated a positive correlation between elevated plasma TMAO and an increased risk for major adverse cardio and cerebrovascular events [9,10], suggesting a TMAO contribution in CVD etiology

So the 100mg format makes sense when your usage rate matches the larger quantity