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While GLP-1based therapies have been part of medical care for years, those medications have traditionally required injection

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Most of this risk was attributed to the rs3798220 variant (below in the genotype report section).[ref] Aortic valve stenosis: For aortic valve stenosis, there is a 3-fold increase in relative risk for those with Lp(a) levels greater than 90 mg/dl.[ref] Higher Lp(a) expression is a risk factor for calcific aortic valve disease

Dosing protocols vary widely across studies, ranging from micrograms to milligrams depending on route and intended outcome