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However, further in vitro assays showed a different pharmacological profile, since although the effect on cAMP was notable, we did not observe additional significant effects on -arrestin recruitment activation, therefore providing a similar profile than other non-peptidic agonists like CHU-128 and TT-OAD2

8:e5077710.7554/eLife.50777 Elife Summary Keywords glutathione peroxidase 1, spiral ganglion neuron, peroxynitrite, oxidative stress, nuclear factor-kappa B, hearing loss Citation Wang X, Han Y, Chen F, Wang M, Xiao Y, Wang H, Xu L and Liu W (2022) Glutathione Peroxidase 1 Protects Against Peroxynitrite-Induced Spiral Ganglion Neuron Damage Through Attenuating NF-B Pathway Activation

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Dysplastic ineffective erythropoiesis is one of the cardinal manifestations of MDS, leading to an insufficient production of mature erythrocytes and potentially to a higher turnover of erythroid progenitors