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However, immunosenescence contributes substantially to morbidity and mortality in later life

GH drives collagen type I synthesis and increases skin thickness effects documented in GH-deficient patients receiving GH replacement (Sjogren et al., 1996)

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IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]