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( A E ) Western blots revealing that, compared to control, FoxO4 knockdown increases protein levels of p53 and Ser15-phospho-p53 but decreases levels of p21 in senescent TM3 Leydig cells

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Stopping a GLP-1 medication does not directly cause muscle loss, but appetite often returns, which can lead to weight regain if resistance training and higher protein habits built during the medication period are not maintained

The genetic test reveals predispositions in peptide metabolic pathwaysnot exact medication response or fatigue likelihood

doi: 10.1186/s12890-021-01575-7 128 ieMRSue-ChuMHelvikASSteinsvagSKSteinsbekkSThorstensenWM