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Comorbidities of diabetes (i.e., hypertension, dyslipidemia, obesity) also have crucial roles in pathophysiology of CKD in diabetes

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

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Uremic toxins and pathogen-associated molecular patterns activate the immune system and sustain systemic inflammation ( Figure 4 ) [34]

Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model