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26 Our finding of increased TSC2 levels in hypertrophic chondrocytes from the CartIR / mice is entirely consistent with loss of insulin signaling through mTOR and likely accounts for the smaller size of these chondrocytes

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In patients with low activity ITPA less TITP is reconverted to TIMP, resulting in higher levels of MeTITP

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Analytical testing methods provide definitive degradation assessment but require specialized equipment