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Open question Whether the same mechanisms are clinically meaningful in humans is not yet established

In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity

A total of 32 participants, aged 20 to 50 years (mean age: 36.5 9.6), were enrolled

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Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context