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Microglial activation is increased in the brains of depressed patients and this increase is correlated with the severity of the depression (Setiawan et al., 2015)

In vivo, suramin demonstrated therapeutic activity in a collagen-induced arthritis rat model, where daily intraperitoneal administration at 10 mg/kg for 3 weeks reduced inflammation and promoted joint repair [192]

Another issue is timing

Cyanocobalamin injections are often prescribed to gastric bypass patients who have had part of their small intestine bypassed, making it difficult for B 12 to be acquired via food or vitamins

Researchers designing studies should carefully consider the evidence gap