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Suppresses Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and IL-1 release through AMPK-dependent autophagy in a HFD-induced IR mice model, countering palmitate-induced inflammation [180]

doi:10.1074/jbc.M602770200

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Under normal conditions, Nrf2 is sequestered in the cytoplasm by its inhibitor protein, Kelch-like ECH-associated protein 1 (Keap1)