Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion
Supplementation with NAC, cysteine, and glycine has been shown to increase GSH levels.
Human ApoE isoforms differentially modulate glucose and amyloid metabolic pathways in female brain: evidence of the mechanism of neuroprotection by ApoE2 and implications for Alzheimers disease prevention and early intervention
Although acyl-CoA synthetase long chain family member 4 (ACSL4) was identified as a pro-ferroptotic gene, the expression of which determines ferroptosis sensitivity 9,10 , inhibition of GPX4 fails to trigger ferroptosis in some cancer cell lines regardless of ACSL4 expression, suggesting that there are alternative resistance mechanisms
Mutations in the CYBA gene account for approximately 5% of CGD cases
In contrast to oridonin alone, orid-liposome has a better efficacy due to its better water solubility