Many patients and providers are curious whether this emerging strategy could improve outcomes while reducing side effects
In STEP UP, a phase 3b randomized trial in 1,407 adults with a BMI of 30 kg/m or greater and without diabetes, mean body weight change at week 72 was 18.7% with semaglutide 7.2 mg versus 15.6% with semaglutide 2.4 mg, an estimated treatment difference of 3.1%
But it depends on the type of test
For women with significant postpartum weight retention, say 30 or more pounds above pre-pregnancy weight, this stronger effect may be appealing
Many of my patients have tried almost everything to heal their gut or their overall well-being, including supplements, bone broth fasts, and elimination diets
Stage A is a multiple ascending dose study, and participants have a 25% chance of receiving placebo