Findings from a 4-day Alternaria alternata extract intranasal challenge model showed that the absence of GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling exacerbated airway inflammation, characterized by increased lung ILC2s, lymphocytes, eosinophils, and neutrophils, as well as heightened pulmonary expression of type 2 cytokines (IL-5, IL-13), chemokines (CCL11, CCL24), and epithelial ICAM-1
American Diabetes Association professional practice committee
As a natural flavonoid in fruits and vegetables, C3G offers a cost-effective, orally available option to complement GLP-1 receptor agonists, with particular benefits for resource-limited settings
The aim is not to stop effective treatment, but to support patients aesthetically throughout their weight-loss journey
Unlike surgical interventions that remain largely inaccessible through NHS pathways, metabolic therapies could potentially be prescribed and monitored within existing healthcare frameworks, making them a more practical option for many UK patients
doi: 10.3389/fimmu.2017.01905 128 GoldenbergRMChengAYYFitzpatrickTGilbertJDVermaSHopyanJJ
