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The STEP program included four phase 3 clinical trials with over 4,500 participants

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These subjective experiences suggest the medications may influence the psychological and neurological drivers of eating beyond simple physiological hunger, though systematic studies confirming these effects are limited

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During obesity-induced adipose tissue remodeling, abnormal secretion of proinflammatory factors and adipokines promotes tumor cell proliferation, invasion, and metastasis, accelerating tumor progression