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Cycle length is typically 4 to 8 weeks, with a clinical review at the midpoint to assess response

secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation

However, in recent years, dedifferentiation, senescence and other forms of cell death, such as autophagy, pyroptosis and ferroptosis, have been found to be involved in the loss of cells

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Sections were fixed in ice-cold 0.5% glutaraldehyde (w/v, PBS) for 15 min and washed with 1 mM MgCl 2 /PBS (pH 6.0) for 5 min