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We have previously identified that Sita (i.e., an DPP4 inhibitor) therapy significantly suppressed the DPP4 activity in circulation which, in turn, markedly increased circulating and tissue levels of SDF-1 and GLP-1 in setting of organ ischemia in rodent [29-32]

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Tirzepatide is FDA-approved (for diabetes and weight loss, depending on the brand) and works as a dual-agonist, targeting GLP-1 and GIP receptors to reduce appetite, improve insulin response, and support weight loss

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The improvement in her lymphedema mirrored her weight loss