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Variation in efficacy and tolerability supports tailoring GLP-1 RA therapy to individual patient characteristics and treatment goals
Existing studies are mostly preliminary, involve small cohorts, and lack long-term randomized controlled trials, which limits the strength of current conclusions
By filling these gaps, supplements can improve energy and overall health
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Some patients report increased abdominal discomfort, cramping, or bloating when initiating therapy, which may be particularly distressing for individuals already experiencing heightened gut sensitivity
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