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Copper ions are highly reactive in solution and can cause rapid hydrolysis (breakdown) of other peptide chains if mixed during manufacturing or long-term storage

If itching is severe or accompanied by a spreading rash, this may indicate a hypersensitivity reaction requiring medical assessment

It has also been hypothesized that reduced frequency selectivity leads to a greater reliance on temporal cues and perhaps to greater susceptibility to distortion of those cues with amplification (Souza, Jenstad & Folino, 2005)

Thioridazine administration produces a dose-related prolongation of the QTc interval, which is associated with serious ventricular arrhythmias, such as torsades de pointes-type arrhythmias, and sudden death

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