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Semaglutide and Tirzepatide also have warnings for the possibility of causing pancreatitis, gallbladder problems, hypoglycemia, acute kidney injury, diabetic retinopathy, increased heart rate, severe gastrointestinal disease, and suicidal behavior or thinking
Clinical trials involving investigational medicinal products (CTIMPs) in the UK are governed by the Medicines for Human Use (Clinical Trials) Regulations 2004 (as amended), with safety reporting requirements set out in MHRA and Health Research Authority (HRA) guidance
In clinical trials, participants who took the highest dose of the once-daily pill achieved an average weight loss of 12.4 percent, or 27.3 pounds, after 72 weeks, compared with 2.2 pounds with the placebo
Endocr Pract 4(2):8285
