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GLP-1 (appetite) + GIP (insulin) + glucagon (energy burn) + amylin (fullness)

10.1002/pmic.200500317 24 ChenI

Fluoxetine-induced androgen deficiency may lead to the increased expression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), which activates the pro-apoptotic factor p53 through deubiquitination and triggers germ cell apoptosis

Notably, our group found the compound to be more potent than reported values for both the hMC4R (EC 50 = 0.053 nM) and the hMC3R (EC 50 = 0.82 nM) ( Table 2 ) (25)