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Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

GSH is one of the most ubiquitous low molecular weight antioxidants in the body, it is expressed at high levels within cells and is found at relatively high levels in some extracellular fluids such as the lung ELF [4] and bile [25]

Biological structure of TrxR As the central enzymatic constituent of the Trx system, TrxR is classified within the pyridine nucleotide-disulfide oxidoreductase family (27)

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