Glucagon-like peptide-1 or GLP-1 medications were first approved for weight loss in 2014 and Wegovy was approved for weight loss in 2021
This culminated in November 2025 deals with Novo Nordisk and Eli Lilly for $245/month government pricing, and the launch of a TrumpRx direct-to-consumer platform offering GLP-1s at approximately $350/month average
These interactions highlight the complex and integrated role of gut-derived peptides in modulating cardiovascular function, emphasizing the therapeutic potential of targeting these pathways in cardiovascular diseases as captured below under gaps and new areas of investigation
Some patients benefit from temporary use of over-the-counter remedies like bismuth subsalicylate or loperamide, though these should be discussed with your healthcare provider first
Einarson TR, Acs A, Ludwig C, Panton UH
And this is what impacts our patients every day