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Initiating estrogen therapy earlier in the menopausal transition, typically within 10 years of the final menstrual period and before age 60, is associated with a more favorable cardiovascular profile [26]

Some patients also experience dose-related side effects that prevent them from reaching higher, more effective dose levels

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doi:10.3904/kjim.1987.2.1.112 [20] Staii A, Mirocha S, Todorova-Koteva K, Glinberg S, Jaume JC

AOD-9604s preferential activity in beta-3 receptor-dense areas may provide the extra push needed in those specific zones

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