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Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms

576 Tetrahydroxy stilbene glycoside (TSG) enhances the activation of Keap1/Nrf2/ARE and GSH/GPX4 signaling pathways, reduces ferroptosis by regulating the levels of ferroptosis-related proteins and enzymes, and thus inhibits the production and deposition of A in the brain of APP/PS1 mice, 577 suggesting that TSG may be a promising therapeutic agent for AD by targeting ferroptosis

However, accurately forecasting cellular responses to particular antioxidants based on current research poses a challenge

2018 Aug 6;2(8):906-918