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The Phase 3 TRIUMPH-4 data extends to 68 weeks and shows 28.7% weight loss, suggesting the drug continues working well beyond the Phase 2 timeframe

These arguments, which center on the molecular effects of OS precursors or modulators, imply that certain anti-inflammatory products might be taken into consideration as part of the antidiabetic treatment, just as they have been for myocardial infarction (Nuez-Musa, 2024)

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Emerging evidence suggests that dual GLP-1/GIP agonists like tirzepatide may offer a more favorable gastrointestinal profile in some patients, potentially improving adherence (Kim et al., 2025)