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Tumor Necrosis Factor Alpha TNF- is a cytokine produced by macrophages, adipocytes, T cells, and endothelial cells

Bariatric surgery has proven to be an effective method in helping obese patients lose a significant amount of weight and maintain that weight loss long-term

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however, continuation of treatment preserved weight loss and further increased total weight reduction

These cells display improved mitochondrial function and proliferation, alongside reduced apoptosis and mtDNA-mediated inflammation, driven by the activation of HIF-1-BNIP3/NIX-mediated mitophagy and an increase in reactive oxygen species (ROS) levels