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This provided a mechanistic link between the compound's structure and its observed effects in preclinical models, suggesting GIPR's role may be particularly important in modulating lipid storage and energy expenditure

When glucagon receptor activation combines with GLP-1 activity, something remarkable happens

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The novel DA-CH3 dual incretin restores endoplasmic reticulum stress and autophagy impairments to attenuate Alzheimer-like pathology and cognitive decrements in the APPSWE/PS1DeltaE9 mouse model

10.1016/j.obmed.2017.06.003 Obesity Medicine